Your browser doesn't support javascript.
loading
The studies for activating and inhibitory receptors on natural killer cells in HIV/HCV co-infected patients / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology ; (6): 182-184, 2011.
Artigo em Chinês | WPRIM | ID: wpr-231156
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the characteristics of inhibitory and activating receptor expressions on natural killer (NK) cells in HIV/HCV co-infected patients.</p><p><b>METHODS</b>Numbers, frequencies and expressions of activating and inhibitory receptors of NK cells were measured with flow cytometry (FCS) from HIV/HCV co-infected group (n = 24), HCV mono-infected group (n = 34), HIV mono-infected group (n = 21) and healthy control group (HC, n = 20), then analysis and compare were performed among those groups.</p><p><b>RESULTS</b>The NK cell absolute counts in HIV/HCV group were significantly lower than those in other three groups. The NKP30 and NKP46 frequencies on NK cells in HIV/HCV, HIV and HCV groups were all significantly lower than those in HC group, but there were no significant differences of NKP30 among former three groups; and NKP46 frequencies in HIV/HCV and HIV groups were lower than those in HCV group, but there were no significant differences between former two groups. The NKG2A frequencies in HIV/HCV and HCV groups were all higher than those in HIV and HC groups significantly, but the NKG2A frequencies in HIV group were lower than those in HC group; There were no significant differences of NKG2D, CD158a and CD158b among those four groups.</p><p><b>CONCLUSION</b>NK cell numbers and expressions of activiting receptors on NK cells obviously decreased in HIV/HCV co-infected patients, but some inhibitory receptors expressions increased, even higher than those of HIV mono-infected patients. NK cells impairments in HIV/HCV co-infection is more severe than HIV or HCV mono-infection.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Células Matadoras Naturais / Infecções por HIV / Hepatite C / Receptores KIR2DL1 / Receptores KIR2DL3 / Receptor 1 Desencadeador da Citotoxicidade Natural / Receptor 3 Desencadeador da Citotoxicidade Natural / Subfamília C de Receptores Semelhantes a Lectina de Células NK / Subfamília K de Receptores Semelhantes a Lectina de Células NK / Citometria de Fluxo Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Experimental and Clinical Virology Ano de publicação: 2011 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Células Matadoras Naturais / Infecções por HIV / Hepatite C / Receptores KIR2DL1 / Receptores KIR2DL3 / Receptor 1 Desencadeador da Citotoxicidade Natural / Receptor 3 Desencadeador da Citotoxicidade Natural / Subfamília C de Receptores Semelhantes a Lectina de Células NK / Subfamília K de Receptores Semelhantes a Lectina de Células NK / Citometria de Fluxo Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Experimental and Clinical Virology Ano de publicação: 2011 Tipo de documento: Artigo