The studies for activating and inhibitory receptors on natural killer cells in HIV/HCV co-infected patients / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 182-184, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-231156
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the characteristics of inhibitory and activating receptor expressions on natural killer (NK) cells in HIV/HCV co-infected patients.</p><p><b>METHODS</b>Numbers, frequencies and expressions of activating and inhibitory receptors of NK cells were measured with flow cytometry (FCS) from HIV/HCV co-infected group (n = 24), HCV mono-infected group (n = 34), HIV mono-infected group (n = 21) and healthy control group (HC, n = 20), then analysis and compare were performed among those groups.</p><p><b>RESULTS</b>The NK cell absolute counts in HIV/HCV group were significantly lower than those in other three groups. The NKP30 and NKP46 frequencies on NK cells in HIV/HCV, HIV and HCV groups were all significantly lower than those in HC group, but there were no significant differences of NKP30 among former three groups; and NKP46 frequencies in HIV/HCV and HIV groups were lower than those in HCV group, but there were no significant differences between former two groups. The NKG2A frequencies in HIV/HCV and HCV groups were all higher than those in HIV and HC groups significantly, but the NKG2A frequencies in HIV group were lower than those in HC group; There were no significant differences of NKG2D, CD158a and CD158b among those four groups.</p><p><b>CONCLUSION</b>NK cell numbers and expressions of activiting receptors on NK cells obviously decreased in HIV/HCV co-infected patients, but some inhibitory receptors expressions increased, even higher than those of HIV mono-infected patients. NK cells impairments in HIV/HCV co-infection is more severe than HIV or HCV mono-infection.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células Matadoras Naturais
/
Infecções por HIV
/
Hepatite C
/
Receptores KIR2DL1
/
Receptores KIR2DL3
/
Receptor 1 Desencadeador da Citotoxicidade Natural
/
Receptor 3 Desencadeador da Citotoxicidade Natural
/
Subfamília C de Receptores Semelhantes a Lectina de Células NK
/
Subfamília K de Receptores Semelhantes a Lectina de Células NK
/
Citometria de Fluxo
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2011
Tipo de documento:
Artigo
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