Bioinformatics analysis of the structure and function correlated to interferon sensitivity of HCV core protein / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 96-98, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-231183
ABSTRACT
<p><b>OBJECTIVE</b>To analyze and predict the structure and function correlated to interferon sensitivity of HCV Core protein in different genotypes.</p><p><b>METHODS</b>Using different bioinformafics software respectively to comparatively analyze and predict the secondary structure, tertiary structure, modification site and main functional motifs of HCV Core protein.</p><p><b>RESULTS</b>There were diversities in secondary structure and tertiary structure of different genotypes. HCV Core protein would exist some modification sites about amidation, cAMP, PKC, TYR, and interact with amphiphysin SH3 domain, ERK, PKC.</p><p><b>CONCLUSION</b>Differences in structure and function of HCV Core protein of different genotypes affected interferon sensitivity.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Conformação Proteica
/
Virologia
/
Dados de Sequência Molecular
/
Química
/
Proteínas do Core Viral
/
Sequência de Aminoácidos
/
Interferons
/
Hepatite C
/
Hepacivirus
/
Biologia Computacional
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2011
Tipo de documento:
Artigo
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