The association between HBV genotyping and clinical characteristics and expression of TH1/TH2 cytokines / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 439-441, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-231225
ABSTRACT
<p><b>OBJECTIVE</b>To explore the association between HBV genotyping and clinical characteristics and expression of TH1/TH2 cytokines.</p><p><b>METHODS</b>The expression of IL-4 and IFN-gamma was detected with flow cytometry for 102 HBV infections and 48 healthy controls. 50 CHB patients were randomly selected for HBV genotyping with real-time fluorescence PCR assay.</p><p><b>RESULTS</b>Higher expression of IL-4 in peripheral blood was detected in patients with HBV infection than healthy controls (P < 0.001); No significant differences on expression of Th1/Th2 cytokines were observed in CHB patients with different HBV DNA levels or HBeAg status (P > 0.05). There were 34 (68%) patients with genotype B infection and 16 (32%) with genotype C infection. Compared to patients with genotype B infection, the patients with genotype C infection showed higher levels of IL-4 (P = 0.018), and Th1/Th2 ratio decreased,but the difference was not statistically significant (P = 0.2262).</p><p><b>CONCLUSION</b>The different expression of TH1/TH2 cytokines may elucidate cellular immune response and clinical outcome difference between patients with genotype B infection and genotype C infection.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Virologia
/
Vírus da Hepatite B
/
Interleucina-4
/
Interferon gama
/
Células Th2
/
Células Th1
/
Hepatite B Crônica
/
Alergia e Imunologia
/
Genética
/
Genótipo
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2010
Tipo de documento:
Artigo
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