Regulatory roles of compound danshen in the downstream path of cyclooxygenases in rheumatoid arthritis patients' synovium / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 1416-1419, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-231670
ABSTRACT
Rheumatoid arthritis (RA) belongs to Bi syndrome (arthralgia) in Chinese medicine. Till now there lacks effective therapeutic methods. Recently cyclooxygenases (COXs) inhibitors, having regulator roles for many pro-inflammatory cytokines, have been widely used in RA treatment. But due to existing cardiovascular risks, researches on targeting the downstream specific factors of COXs have been under discussion. Considering the key role of blood stasis syndrome (BSS) in the pathology of RA and the fact that thromboxane A2 (TXA2) plays a pivotal role in BSS, we theoretically explored possible regulatory roles of Compound Danshen, a representative therapy in blood activating stasis removing method in the downstream path of COXs in synovial cells of RA. We proposed a brand new research direction of RA researches.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Artrite Reumatoide
/
Membrana Sinovial
/
Medicamentos de Ervas Chinesas
/
Química
/
Prostaglandina-Endoperóxido Sintases
/
Salvia miltiorrhiza
/
Diagnóstico
/
Medicina Tradicional Chinesa
/
Metabolismo
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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