Differential expression profiles of microRNAs/mRNA and docking study in oral squamous cell carcinoma / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 400-403, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-231840
ABSTRACT
<p><b>OBJECTIVE</b>To construct and analyze the differential expression profiles of microRNAs (miRNA) and mRNA in oral squamous cell carcinoma (OSCC). To explore the miRNA and mRNA of OSCC development and progression.</p><p><b>METHODS</b>The differential expression profiles of miRNA and mRNA were built by high-throughput deep sequencing technology. Using Gene Ontology (GO) enrichment analysis, the roles of differentially expressed miRNA and mRNA in cell cycle, cell proliferation, cell differentiation and cell apoptosis were analyzed.</p><p><b>RESULTS</b>Seventy-seven differentially expressed miRNA and 1 298 differentially expressed mRNAs were identified in OSCC. GO analysis showed that 73 miRNA had found target mRNA in cell cycle, cell proliferation, cell differentiation and cell apoptosis of OSCC. Moreover, a miRNA could regulate multiple mRNA.</p><p><b>CONCLUSION</b>The differential expression profiles of miRNA and mRNA have close relationship with the development and progression of OSCC.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
RNA Mensageiro
/
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Regulação Neoplásica da Expressão Gênica
/
Apoptose
/
MicroRNAs
/
Proliferação de Células
Limite:
Humanos
Idioma:
Chinês
Revista:
West China Journal of Stomatology
Ano de publicação:
2014
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS