Role of PD153035 in the induction of apoptosis of XG-1 myeloma cell line / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 492-495, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-231901
ABSTRACT
<p><b>OBJECTIVE</b>To study the role of epidermal growth factor receptor (EGFR) in the proliferation and survival of human myeloma cells.</p><p><b>METHODS</b>The inhibitor of EGFR, PD153035, was used to block the signal transduction of EGFR. The proliferation and apoptosis of myeloma cell line, XG-1, were detected by 3H-TCR incorporation assay and Annexin V staining analysis, respectively. The phosphatation of STAT3, the key activate signal to the myeloma cell proliferation, was detected with Western blot.</p><p><b>RESULTS</b>PD153035 decreased the proliferation of XG-1 and induced an obvious apoptosis in XG-1. The phosphatation of STAT3 induced by HB-EGF but not by IL-6 was blocked by PD153035.</p><p><b>CONCLUSION</b>The proliferation and survival of myeloma cells may be suppressed by PD153035 due to the blockage of phosphatation of STAT3 induced by the activation of EGFR.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Quinazolinas
/
Transativadores
/
Divisão Celular
/
Apoptose
/
Linhagem Celular Tumoral
/
Proteínas de Ligação a DNA
/
Fator de Transcrição STAT3
/
Receptores ErbB
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2004
Tipo de documento:
Artigo
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