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Detection of eotaxin and its clinical diagnosis value in patients with bronchial asthma / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 298-301, 2004.
Artigo em Chinês | WPRIM | ID: wpr-231941
ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of eotaxin in the pathogenesis of bronchial asthma and the clinical value in the diagnosis of asthma.</p><p><b>METHODS</b>Serum eotaxin were measured by ELISA in 38 patients with asthma, 28 patients with non-asthma allergy, and 30 healthy controls.</p><p><b>RESULTS</b>The levels of serum eotaxin in the asthma group were higher than those in the non-asthma allergic and control group (P<0.01). Furthermore, eotaxin levels in patients with acute asthma were significantly higher than those in patients with stable asthma (P<0.001). It was also found that the eotaxin levels of the acute asthma group were positively correlated to the amounts of eosinophils in peripheral blood (r=0.4196, P<0.001), and inversely correlated to the forced expiratory volume in one second (FEV1) (r=-0.3746, P<0.001).</p><p><b>CONCLUSION</b>It suggests that eotaxin may play a crucial pathogenic role in the asthmatic process possibly by activating the allergic inflammatory cells and controlling the recruitment of eosinophils from blood to bronchial epithelium of the airway. The concentration of eotaxin is significantly associated with the attack of acute asthma and its severity. Eotaxin may be a potential therapeutic target in patients with asthma.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Fisiologia / Asma / Sangue / Contagem de Células / Volume Expiratório Forçado / Quimiocinas CC / Diagnóstico / Eosinofilia / Quimiocina CCL11 Tipo de estudo: Estudo diagnóstico Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Acta Academiae Medicinae Sinicae Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Fisiologia / Asma / Sangue / Contagem de Células / Volume Expiratório Forçado / Quimiocinas CC / Diagnóstico / Eosinofilia / Quimiocina CCL11 Tipo de estudo: Estudo diagnóstico Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Acta Academiae Medicinae Sinicae Ano de publicação: 2004 Tipo de documento: Artigo