Changes of plasma adrenomedullin level during the process from chronic bronchitis to chronic cor-pulmonale / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the relationship between the plasma adrenomedullin (ADM) levels and the extent of chronic cor-pulmonale and its underlying diseases, and explore the role of ADM in these diseases.</p><p><b>METHODS</b>Totally 26 patients with chronic bronchitis, chronic bronchitis accompanied with obstructive pneumonectasia or chronic cor-pulmonale were included respectively as clinical test group T1, T2 and T3; 26 normal people and 14 patients with pneumonia were chosen as control groups (group C1 and C2). Plasma concentration of ADM in every selected individual had been measured with specific radioimmunoassay.</p><p><b>RESULTS</b>Levels of plasma ADM in T3 were significantly higher than those in T2, and T2 than T1, C1 and C2 (P < 0.05), but there were no obvious difference between T1 and C1, between T1 and C2 (P > 0.05).</p><p><b>CONCLUSIONS</b>Plasma ADM levels can reflect the severity of the above series of diseases.</p>