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Effects of nasal continuous positive airway pressure on serum leptin concentration and the metabolic parameters in obstructive sleep apnea hypopnea syndrome / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 168-171, 2004.
Artigo em Chinês | WPRIM | ID: wpr-231966
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effects of nasal continuous positive airway pressure (nCPAP) on serum leptin concentration and the metabolic parameters in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS).</p><p><b>METHODS</b>Serum leptin levels and true insulin (TI) levels were measured before and after one night nCPAP therapy in 18 patients. Eight patients received regular nCPAP treatment and had no change of body weight (BMI change < or = 1.5 kg/m2 from baseline) were recruited to the reassessment study 7.5 months after therapy.</p><p><b>RESULTS</b>After one night use of nCPAP, there was a significant decrease in serum leptin [(8.47 +/- 0.62) microg/L vs (7.32 +/- 0.64) microg/L, P = 0.022] without change in other parameters. After 7.5 months of nCPAP treatment, serum leptin levels continued to decrease significantly without changes in BMI [(8.35 +/- 0.83) microg/L vs (6.05 +/- 0.78) microg/L; P = 0.036), and fast blood glucose (FBG) and true insulin (TI) also decreased significantly (P = 0.036) in OSAHS patients. However, triglyceral (TG) and cholesterol (Chol) maintained the pretreatment level (P > 0.05).</p><p><b>CONCLUSIONS</b>OSAHS may have significant effects on the serum leptin levels and the correction of sleep disordered breathing by nCPAP can reduce the serum leptin levels. Decrease of leptin was independent of BMI change. The glucose metabolic disturbance and insulin resistance in OSAHS were improved after 7.5 months of nCPAP treatment.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Terapêutica / Sangue / Apneia Obstrutiva do Sono / Leptina / Pressão Positiva Contínua nas Vias Aéreas Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Acta Academiae Medicinae Sinicae Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Terapêutica / Sangue / Apneia Obstrutiva do Sono / Leptina / Pressão Positiva Contínua nas Vias Aéreas Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Acta Academiae Medicinae Sinicae Ano de publicação: 2004 Tipo de documento: Artigo