Anti-apoptotic effect of the androgen receptor in human prostate cancer / 中华男科学杂志
National Journal of Andrology
;
(12): 1121-1124, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-231999
ABSTRACT
Prostate cancer is one of the common cancers in old men. Androgen ablation is a major option for the treatment of the metastatic diseases. However, most of the cancers progress to a more aggressive stage, so-called androgen-independent (or hormone refractory) relapse beyond any cure. The androgen receptor (AR) is an important factor in regulating the differentiation and proliferation of prostate epithelial cells, and also plays a critical role in cellular survival. Studies have demonstrated that aberrant activation of the AR is a major determinant in prostate cancer progression. We have provide a brief summary of AR-mediated cellular survival and an introduction to the advances of RNA interference techniques in silencing AR expression as a novel therapy for prostate cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fisiologia
/
Neoplasias da Próstata
/
Receptores Androgênicos
/
Regulação Neoplásica da Expressão Gênica
/
Apoptose
/
Interferência de RNA
/
Genética
Limite:
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2007
Tipo de documento:
Artigo
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