Genome-wide linkage scan for an ethnic Han Chinese pedigree affected with schizophrenia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 5-8, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-232217
ABSTRACT
<p><b>OBJECTIVE</b>To perform genome-wide linkage analysis for an ethnic Han Chinese pedigree with schizophrenia in order to locate the susceptibility genes.</p><p><b>METHODS</b>Genomic DNA was extracted from 4 mL of peripheral blood using conventional phenol-chloroform method. Illumina Infinium Linkage 24 BeadChips chip was used for determining the genotypes through detection of single nucleotide polymorphisms (SNPs). After processing the raw data using Illumina BeadStudio software, two-point nonparametric linkage analysis and two-point parametric linkage analysis were performed with Merlin software.</p><p><b>RESULTS</b>By two-point nonparametric linkage analysis, 27 sites with high LOD scores (LOD=0.63-0.75, P U+003C 0.05) were identified. Among these, 3 SNPs(rs993694, rs992690 rs1861577) were located in 12p12.3 region, whilst the remainders were located in 4p12-q22 region. Two-point parametric linkage analysis under a dominant model has yielded almost identical results.</p><p><b>CONCLUSION</b>Chromosomal regions 4p12-q22 and 12p12.3 probably contain susceptibility genes for schizophrenia.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Linhagem
/
Esquizofrenia
/
Cromossomos Humanos Par 4
/
Cromossomos Humanos Par 12
/
China
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
/
Estudo de Associação Genômica Ampla
/
Genética
/
Genótipo
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2013
Tipo de documento:
Artigo
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