Association between GIRK4 gene polymorphisms and insulin resistance in Xinjiang Uygur population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 715-719, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-232224
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association between polymorphisms of protein-activated inwardly rectifying K+ channel (GIRK4) gene and insulin resistance (IR) in Xinjiang Uygur population.</p><p><b>METHODS</b>A cross-sectional epidemiological survey-based case-control study was carried out, for which 1295 subjects (including 324 IR patients and 971 non-IR controls) were randomly selected. Functional region of the GIRK4 gene was sequenced for 48 randomly selected IR patients. Representative variable sites were chosen, with its association with IR assessed in 1295 Uygur subjects.</p><p><b>RESULTS</b>rs11221497 variant was associated with IR in Uygur subjects under 50 years old (P=0.017 in genotype model, P=0.009 in dominant model). Subjects with dominant model of CC genotype have an OR of 1.833 (95%CI 1.157-2.905) for IR.</p><p><b>CONCLUSION</b>GIRK4 gene polymorphisms may be associated with IR in Uygur ethnics from Xinjiang. The CC genotype of rs11221497 variant is a risk factor for IR.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Resistência à Insulina
/
Estudos de Casos e Controles
/
Fatores de Risco
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Alelos
/
Canais de Potássio Corretores do Fluxo de Internalização Acoplados a Proteínas G
/
Frequência do Gene
/
Genética
/
Genótipo
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2012
Tipo de documento:
Artigo
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