Association between various rs501120 genotypes and progress of unstable coronary atherosclerotic plaque in diabetes mellitus complicated with acute coronary syndrome / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To assess the association between single nucleotide polymorphism rs501120 and progress of unstable coronary atherosclerotic plaque in diabetes mellitus complicated with acute coronary syndrome (ACS).</p><p><b>METHODS</b>Nine hundred and two patients with diabetes complicated with acute coronary syndrome were enrolled. The genotype of rs501120 was determined with TaqMan-MGB probes. Two hundred and five cases of TT genotype, 205 age-and sex-frequency-matched cases of TC genotype and 205 age- and sex-frequency-matched cases of CC genotype were chosen and followed up for 3 years. Clinical data and re-occurrences of ACS were recorded.</p><p><b>RESULTS</b>Patients with TT genotype had a significantly higher incidence of recurrence of ACS than those with CC genotype (TT vs. CC OR 1.7, 95%CI 1.1-2.7, P= 0.02). And the significance has remained even after adjusting for conventional risk factors by logistic regression (OR 1.6, 95% CI1.05-3.6, P= 0.03). Patients with TT genotype had a significantly higher incidence of myocardial infarction than those with CC genotype(TT vs. CC OR 1.9, 95% CI 1.2-3.2, P= 0.007).</p><p><b>CONCLUSION</b>Our results has suggested an association between the rs501120 polymorphism and progress of unstable coronary atherosclerotic plaque.</p>