Pre-Clinical Study of Risperidone / 대한정신약물학회지

ABSTRACT

Pre-clinical study has been carried out to explore the pharmacology, mechanism of actions, and toxicology of candidate materials for the new therapeutic drugs, and the additional biological mechanisms of drugs prescribed presently in clinical practice. The in vitro study has been applied for the mechanism of actions at the molecular level, drug resistance, determining factors on drug responses, intracellular pharmacodynamics, and molecular pharmacology, and the in vivo study for the therapeutic effects in living animals, toxicology, and determination of initial clinical doses. The pre-clinical studies of risperidone have been reported in Korea only a few papers of biochemical studies related with dopamine neurotransmission, Fos-immunoreactivity, animal models of obsessivecompulsive disorder, and neuroprotection in dementia. In this manuscript, some issues focused on the pre-clinical studies of risperidone in Korea were summarized with the journal reviews through the PubMed.