Expressions of SMG-1, ATM and P53 in laryngeal squamous cell carcinoma and their clinical significance / 南方医科大学学报
Journal of Southern Medical University
; (12): 50-55, 2016.
Article
em Zh
| WPRIM
| ID: wpr-232512
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of SMG-1, ATM and P53 in laryngeal squamous cell carcinoma (LSCC) and their correlation with the clinicopathological features and outcomes of the patients.</p><p><b>METHODS</b>Sixty-three specimens of surgically resected LSCC tissues and 30 specimens of adjacent normal tissue were examined for the expressions of ATM, SMG-1 and P53 using immunohistochemistry. The correlation of ATM, SMG-1 and P53 expressions with the clinicopathological factors and their interactions were analyzed.</p><p><b>RESULTS</b>The positive expression rates of SMG-1, ATM and P53 in LSCC were 36.5% (23/63) , 41.3% (26/63) and 57.1% (36/63) respectively, significantly different from those in the adjacent tissue (73.3%, 83.3% and 20.0%, respectively; P<0.05). The expression of SMG-1 in LSCC was positively correlated with the pathological grade and T stage of the tumors (P<0.05), and ATM and P53 were not related to the clinicopathological factors (P>0.05). The 5-year survival rate of patients negative for SMG-1 expression was significantly higher than that of SMG-1-positive patients (P<0.05). The expression of SMG-1 was negatively correlated with that of P53 (r=-0.476, P<0.01).</p><p><b>CONCLUSION</b>SMG-1, ATM and P53 are closely related to the occurrence of LSCC. SMG-1 expression is an important factor associated with the clinicopathological features and prognosis of LSCC patients, and may play an important role in the development of LSCC by regulating P53 expression.</p>
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Índice:
WPRIM
Assunto principal:
Prognóstico
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Imuno-Histoquímica
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Carcinoma de Células Escamosas
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Neoplasias Laríngeas
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Taxa de Sobrevida
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Proteína Supressora de Tumor p53
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Fosfatidilinositol 3-Quinases
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Proteínas Mutadas de Ataxia Telangiectasia
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Genética
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Metástase Linfática
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2016
Tipo de documento:
Article