Expressions of ZEB2 and C-myc in epithelial ovarian cancer and their clinical significance / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1765-1769, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-232530
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression patterns of ZEB2 and C-myc in epithelial ovarian cancer (EOC) and the associations between their expressions and the pathological features of EOC.</p><p><b>METHODS</b>The expressions of ZEB2 and C-myc proteins were detected immunohistochemically in 191 cervical cancer tissues and 13 normal ovarian tissues. The relationship between ZEB2 and C-myc protein expressions and the clinicopathological features of EOC was evaluated.</p><p><b>RESULTS</b>ZEB2 positive expression ratea in EOC tissues and normal ovarian tissues were 49.2% (94/191) and 30.8% (4/13), respectively (P=0.007), and C-myc positive expression rates in the two tissues were 53.9% (103/191) and 15.4% (2/13), respectively (P=0.001). A high expression of ZEB2 was positively correlated with the pathological type of the tumor (P=0.003), FIGO stage (P=0.028), T stage (P=0.002), and N stage (P=0.04), and a high expression of C-myc was positively correlated with FIGO stage (P=0.035), histological grade (P=0.039), and T stage (P=0.002). C-myc and ZEB2 expressions were positively correlated in EOC (P<0.001), and their co-expression in EOC was significantly correlated with T stage (R=0.358, P<0.001) and FIGO stage (P=0.008).</p><p><b>CONCLUSION</b>ZEB2 and C-myc can promote the progression, invasion and metastasis of EOC, and their combined detection may assist in early diagnosis of EOC.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Ovarianas
/
Prognóstico
/
Proteínas Repressoras
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Proteínas Proto-Oncogênicas c-myc
/
Neoplasias Epiteliais e Glandulares
/
Proteínas de Homeodomínio
/
Progressão da Doença
/
Homeobox 2 de Ligação a E-box com Dedos de Zinco
/
Genética
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2015
Tipo de documento:
Artigo
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