Effect of arginine vasopressin on alveolar fluid clearance in rats with acute lung injury / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effect of arginine vasopressin (AVP) on alveolar fluid clearance (AFC) in acute lung injury (ALI).</p><p><b>METHODS</b>Forty-eight healthy adult Sprague-Dawley rats were randomly divided into control group, ALI model group and AVP treatment group. The pathological changes in the lungs, lung water content, alveolar permeability and AFC were observed, and the expressions of alveolar epithelial sodium channel (ENaC) and Na⁺, K⁺-ATPase were measured.</p><p><b>RESULTS</b>Compared with those in the model group, the rats treated with AVP showed significantly decreased alveolar permeability (0.27 ± 0.15 vs 0.59 ± 0.19) and lung water content (5.01 ± 1.59 vs 8.67 ± 1.79) (P<0.05) and increased AFC (23.56 ± 4.51 vs 8.28 ± 3.57) and of α-ENaC expressions (1.296 ± 0.322 vs 0.349 ± 0.141) and α1-Na⁺, K⁺-ATPase (1.421 ± 0.389 vs 0.338 ± 0.186) (P<0.05).</p><p><b>CONCLUSION</b>AVP can promote AFC in with ALI possibly by up-regulation of α-ENaC, α1-Na⁺, and K⁺-ATPase.</p>