Recent advances in the structure-activity relationship study of small-molecule sodium channel blockers with analgesic effects / 药学学报
Acta Pharmaceutica Sinica
;
(12): 101-108, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-232589
ABSTRACT
Pain is one of the common clinical symptom, previous studies have implicated sodium channels as a key constituent in pain signaling. Sodium channel blockers with efficient sodium channel blockade effect play an important role in analgesic treatment. However, most drugs used in clinic have many drawbacks and can not meet the demand of the clinical use. Therefore, for the development of new generation of sodium channel blockers, it is of great significance to find small molecule sodium channel blocking lead compounds with novel chemical scaffolds and new structures, sodium channel blocking activity and structure-activity relationship are discussed in detail, and current problems and trends in future research are also emphasized.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dor
/
Farmacologia
/
Relação Estrutura-Atividade
/
Medição da Dor
/
Desenho de Fármacos
/
Estrutura Molecular
/
Canais de Sódio
/
Química
/
Bloqueadores dos Canais de Sódio
/
Usos Terapêuticos
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS