Effects of beta-lactam antibiotics on development of tolerance and dependence to morphine / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1094-1098, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-232637
ABSTRACT
In order to identify ceftriaxone and its analogs whether has the function of anti-tolerance of morphine and study the dose-effect relation of ceftriaxone in mice, hot plate method to measure pain threshold of mouse and naloxone withdrawal models were carried out and compared with normal saline group. Ceftriaxone and cefotaxime had the effect of anti-tolerance and anti-dependence of morphine notably. And ceftriaxone has the effect of anti-tolerance of morphine in a dose dependent manner.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Síndrome de Abstinência a Substâncias
/
Ceftriaxona
/
Distribuição Aleatória
/
Cefotaxima
/
Limiar da Dor
/
Relação Dose-Resposta a Droga
/
Tolerância a Medicamentos
/
Antibacterianos
/
Morfina
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2008
Tipo de documento:
Artigo
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