Characterization of microstructure of ibuprofen-hydroxypropyl-beta-cyclodextrin and ibuprofen-beta-cyclodextrin by atomic force microscope / 药学学报
Acta Pharmaceutica Sinica
; (12): 969-973, 2008.
Article
em Zh
| WPRIM
| ID: wpr-232658
Biblioteca responsável:
WPRO
ABSTRACT
The microstructures of ibuprofen-hydroxypropyl-bets-cyclodextrin (IBU-HP-beta-CyD) and ibuprofen-beta-cyclodextrin (IBU-beta-CyD) were observed by atomic force microscope (AFM). The high resolving capability of AFM has the tungsten filament probe with the spring constant of 0.06 N x m(-1). Samples were observed in a small scale scanning area of 10.5 nm x 10.5 nm and 800 x 800 pixels. The original scanning images were gained by tapping mode at room temperature. Their three-dimensional reconstruction of microstructure was performed by G3DR software. The outer diameters of HP-beta-CyD and beta-CyD are 1.53 nm. The benzene diameter of IBU is 0.62 nm, fitting to the inner diameters of HP-beta-CyD and beta-CyD. The benzene and hydrophobic chain of IBU enter into the hole of cyclodextrin at 1:1 ratio. The results were evidenced by IR, X-ray diffraction and the phase solubility.
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Índice:
WPRIM
Assunto principal:
Espectrofotometria Infravermelho
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Difração de Raios X
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Química
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Ibuprofeno
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Sistemas de Liberação de Medicamentos
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Microscopia de Força Atômica
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Analgésicos não Narcóticos
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Beta-Ciclodextrinas
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2-Hidroxipropil-beta-Ciclodextrina
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Métodos
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2008
Tipo de documento:
Article