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Property of liposomal fusion induced by acid-sensitive polymer / 药学学报
Acta Pharmaceutica Sinica ; (12): 951-955, 2008.
Artigo em Chinês | WPRIM | ID: wpr-232661
ABSTRACT
The fusion between liposome-liposome, liposome-biomembarnes induced by acid-sensitive polymers has been systematically investigated. The polymer-liposomes were constructed by post-insertion method with the poly (2-ethylacrylic acid) (PEAA) alkylamide derivatives. The liposomal fusion was studied by use of fluorescence resonance energy transfer assay, particle size, fluorescent-photometer. The results indicated that the poly (2-ethylacrylic acid)-liposomes has very strong acidic induced fusion capability. Under acidic conditions, acid-sensitive polymer liposomes fused each other, the fusion closely related to the molecular weight of acid sensitivity polymer on the surface of liposomes. The acidic fusion of polymer-liposomes was dependent upon the lipids composition, the degree of fusion was reversely related to the cholesterol contents. Acid-en ci-nsitive polymer liposomes fused with erythrocyte ghosts. The liposomal fusion induced by acid-sensitive polymer associated with the increase of membrane permeability. The good acid-sensitivity of PEAA has been further demonstrated by membrane fusion in current experiments, and the liposomes prepared with lipid anchored-poly (2-ethylacrylic acid) were developeds s a potential pH sensitive delivery system.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tamanho da Partícula / Polímeros / Temperatura / Acrilatos / Portadores de Fármacos / Química / Sistemas de Liberação de Medicamentos / Alquilação / Membrana Eritrocítica / Concentração de Íons de Hidrogênio Limite: Humanos Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tamanho da Partícula / Polímeros / Temperatura / Acrilatos / Portadores de Fármacos / Química / Sistemas de Liberação de Medicamentos / Alquilação / Membrana Eritrocítica / Concentração de Íons de Hidrogênio Limite: Humanos Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2008 Tipo de documento: Artigo