Significant role of poloxamer in drug transport across blood-brain barrier / 药学学报
Acta Pharmaceutica Sinica
;
(12): 890-897, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-232672
ABSTRACT
Poloxamers are found to be an efficient adjuvant with multiple effects and are applied generally in pharmaceutical field. In recent years, it is investigated that poloxamers can increase the permeability of a broad spectrum of drugs through blood-brain barrier (BBB) by means of manifold mechanisms included (1) inhibiting P-glycoprotein and multidrug-resistance associated protein efflux systems on BBB; (2) adsorbing different apolipoproteins in plasma on the surface of poloxamer-coated nanoparticles, which could interact with BBB through different receptors and mechanisms; (3) connecting to specific ligands and monoclonal antibodies to cross the BBB via specific endogenous transporters localized within the brain capillary endothelium. Significant roles of poloxamer in drug transport across BBB are considered in this review which provides for important guidance to the design of brain-targeted drug delivery system.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Permeabilidade
/
Farmacologia
/
Encéfalo
/
Portadores de Fármacos
/
Barreira Hematoencefálica
/
Química
/
Sistemas de Liberação de Medicamentos
/
Transportadores de Cassetes de Ligação de ATP
/
Subfamília B de Transportador de Cassetes de Ligação de ATP
/
Poloxâmero
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2008
Tipo de documento:
Artigo
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