Association of G-894T and T-786C polymorphisms of endothelial nitric oxide synthase gene with sporadic intracranial aneurysms / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the relationship between 2 polymorphic loci (G-894T and T-786C) of endothelial nitric oxide synthase (eNOS) gene and sporadic intracranial aneurysms.</p><p><b>METHODS</b>Two eNOS gene polymorphisms at G-894T and T-786C were genotyped using polymerase chain reaction-restriction fragment length polymorphism analysis. The genotype and allele frequencies were calculated for the patients and the control group and the association between the gene polymorphisms and the size of aneurysms was analyzed.</p><p><b>RESULTS</b>Significant differences were found in the genotype distribution for eNOS G-894T polymorphism between the patient and control groups. The GG genotype was associated with a higher risk of intracranial aneurysm than GT+TT genotype (OR1.897, 95%CI 1.023-3.519, P=0.04). The patients with intracranial aneurysms had a significantly higher eNOS T-786C C allele frequency than the control group. The C allele was associated with a higher risk of intracranial aneurysm than T allele (OR 2.116, 95%CI 1.073-4.151, P=0.030). No significant association was found between the eNOS polymorphisms and the size of aneurysms.</p><p><b>CONCLUSION</b>eNOS gene may be involved in the occurrence and development of intracranial aneurysms.</p>