Detection of plasma cofilin protein for diagnosis of lung cancer / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To detect serum content of cofilin protein in patients with lung cancer and investigate its clinical value.</p><p><b>METHODS</b>The serum content of cofilin protein was detected in 30 cases of lung cancer and 30 healthy control subjects using enzyme-linked immunosorbent assay.</p><p><b>RESULTS</b>The mean serum content of cofilin protein was 0.485∓0.465 ng/ml in patients with lung cancer and 0.203∓0.102 ng/ml in the control subjects, showing a significant difference between them (P<0.05). The content of cofilin protein in patients with stage III and IV lung cancer 0.744∓0.584 ng/ml, significantly higher than that in stage II patients (0.257∓0.126 ng/ml).</p><p><b>CONCLUSION</b>Serum cofilin protein is elevated in patients with lung cancer, especially in cases in advanced stages, suggesting its relation with lung cancer staging.</p>