Prediction of the possible tertiary structure alterations of p53 protein following point mutation in p53 gene condon 282 in lung cancer cells / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1458-1459, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-232860
ABSTRACT
This study was carried out to predict the possible tertiary structure alterations of p53 protein after point mutation of p53 gene condon 282 in lung cancer cells based on the latest 3D structure analysis platform series of Phyre software. It was found that the p53 gene condon 282 mutation (Arg/Leu) may destabilize the H2 helix and DNA binding in the major groove by compromising the contacts of p53 protein with the beta-hairpin of DNA binding surface.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Códon
/
Dados de Sequência Molecular
/
Sequência de Bases
/
Modelos Moleculares
/
Química
/
Proteína Supressora de Tumor p53
/
Sequência de Aminoácidos
/
Estrutura Terciária de Proteína
/
Mutação Puntual
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2006
Tipo de documento:
Artigo
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