Histological observations of chemically induced acute hepatic injury repaired by allogeneic bone marrow stem cell transplantation / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To explore the possibility of repairing chemically induced acute hepatic injuries with allogeneic bone marrow stem cell (BMSC) transplantation.</p><p><b>METHODS</b>A SD rat model of CCl(4)-induced acute hepatic injury was established, which received transplantation of BMSCs (2.0 ml, 1x10(6)/ml) or normal saline injection into the local liver parenchyma, respectively. The rats were sacrificed at 6 h before and 6 h, 1, and 5 weeks after transplantation, and the livers were prepared for microscopic examination.</p><p><b>RESULTS</b>Cellular necrosis, bridging necrosis, congestion in the hepatic sinusoid, and inflammatory cell infiltration were seen in the chemically injured livers 6 h after model establishment, and these changes were ameliorated in rats receiving BMSC transplantation.</p><p><b>CONCLUSIONS</b>Allogeneic BMSC transplantation can repair chemically induced acute liver injuries.</p>