A Comparative Clinical Study of Prophylatic Effect of Intravesical Instillation with Thiotepa and Mitomycin C after TUR for Superficial Bladder Tumor / 대한비뇨기과학회지
Korean Journal of Urology
;
: 23-28, 1988.
Artigo
em Coreano
| WPRIM
| ID: wpr-23295
ABSTRACT
In a prospective study without crossover design, we were to compare the efficacy of Thiotepa and Mitomycin C when each was instilled intravesically after complete transurethral resection of all visible superficial bladder cancer(stage Ta, Tis and Tl) in 89 consecutive patients. The 3-months and 1year rates free of recurrence were 85.7 and 82.1 percent, respectively for Thiotepa(28 patients), 86.4 and 81.8 percent for Mitomycin C(22 patients), and 79.5 and 56.4 percent for control group(39 patients). Although Thiotepa intravesical instillation demonstrated effectiveness slightly superior to that of Mitomycin C, no significance difference in recurrence and progression rate was noted for either drug group. No patient required discontinuation of therapy in either group because of toxicity although 3 patients required temporary discontinuation of therapy secondary to myelosuppression (2) and symptomatic cystitis(1) in Thiotepa group, and 5 patients secondary to symptomatic cystitis(3) and rash or contact dermatitis(2) in mitomycin C group. This results suggest that Thiotepa is more useful and effective than Mitomycin C for the prophylactic treatment of superficial bladder tumor in cost saving, acceptable toxicity and patients`s convenience, in addition to decreasing the recurrence rate.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Recidiva
/
Bexiga Urinária
/
Neoplasias da Bexiga Urinária
/
Administração Intravesical
/
Estudos Prospectivos
/
Mitomicina
/
Redução de Custos
/
Tiotepa
/
Estudos Cross-Over
/
Tratamento Farmacológico
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Urology
Ano de publicação:
1988
Tipo de documento:
Artigo
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