Identification of the metabolites of Sinisan extract in rat plasma, urine, feces and bile after intragastric administration / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1374-1379, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-232980
ABSTRACT
Sinisan is a widely used traditional Chinese medicine (TCM) in treating various diseases; however, the in vivo metabolic profile of its multiple components remains unknown. In this paper, ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) was applied to identify the metabolites of Sinisan extract in rat plasma, urine, feces and bile after intragastric administration. Using MS(E) and mass defect filter techniques, 41 metabolites of 10 parent compounds (naringin, naringenin, hesperidin, neohesperidin, liquiritin, liquiritigenin, glycyrrhizic acid, glycyrrhetinic acid, saikosaponin a and saikosaponin d) were detected and tentatively identified. It was shown by our results that these compounds was metabolized to the forms of hydroxylation, glucuronidation, sulfation, glucuronidation with sulfation and glucuronidation with hydroxylation in vivo.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plantas Medicinais
/
Medicamentos de Ervas Chinesas
/
Farmacocinética
/
Distribuição Aleatória
/
Química
/
Administração Oral
/
Cromatografia Líquida de Alta Pressão
/
Ratos Sprague-Dawley
/
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
/
Ácido Glicirrízico
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2011
Tipo de documento:
Artigo
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