Absorption dynamic characteristics of clopidogrel bisulfate polymorphs in rat / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1268-1272, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-232999
ABSTRACT
Four crystalline forms of clopidogrel bisulfate were characterized by analytical techniques. Aiming to research the absorption characteristics of clopidogrel bisulfate polymorphs after taken orally by rat, and to estimate the influence of crystal form to pharmacodynamic action, four crystalline forms of clopidogrel bisulfate were administered intragastrically to rats, and high performance liquid chromatography (HPLC) was used to measure the contents of clopidogrel bisulfate and its metabolite in rat plasma. The metabolite of clopidogrel bisulfate was detected in rat plasma. There were significant deviations among four crystalline forms in the areas under curve of the metabolite of clopidogrel bisulfate. We concluded that the different crystal forms of clopidogrel bisulfate showed different pharmacokinetic characteristics, which might affect pharmacodynamic action.
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espectrofotometria Infravermelho
/
Difração de Raios X
/
Sangue
/
Ticlopidina
/
Varredura Diferencial de Calorimetria
/
Farmacocinética
/
Inibidores da Agregação Plaquetária
/
Distribuição Aleatória
/
Química
/
Administração Oral
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2011
Tipo de documento:
Artigo
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