The receptors and entry of measles virus: a review / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1-9, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-233275
ABSTRACT
Measles virus is an enveloped virus with a non-segmented negative-sense RNA genome. Two envelope glycoproteins on the viral surface, namely hemagglutinin (H) and membrane fusion protein (F), are responsible for the virus entry into susceptible host cells. The specific interaction between H and its cellular receptors is a key step in successful virus infection, determining the infectivity and tissue tropism of the measles virus. Thus far, three H receptors have been identified, including the complement regulatory molecule CD46, the signaling lymphocyte activation molecule (SLAM) and the cell adhesion molecule Nectin-4. Here, we reviewed our molecular understanding on the recognition mechanism of these receptors by the viral H protein, aiming to promote future studies on antiviral drug design and measles virus-based oncolytic therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Receptores Virais
/
Virulência
/
Antígenos CD
/
Moléculas de Adesão Celular
/
Receptores de Superfície Celular
/
Proteína Cofatora de Membrana
/
Proteínas de Fusão de Membrana
/
Membro 1 da Família de Moléculas de Sinalização da Ativação Linfocitária
/
Hemaglutininas Virais
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2013
Tipo de documento:
Artigo
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