Role of B-cell-activating-factor in immune regulation--review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 631-634, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-233529
ABSTRACT
B cell activating factor (BAFF) is one of the TNF family member, regulates the survival and maturation of B lymphocyte. BAFF binds to three receptors BCMA, TACI and BAFF-R. In recent years, studies have revealed important roles of BAFF and its receptors in immune regulation of antibody isotype switching, germinal center maintenance, and T cell co-stimulation, that may provide new drugs in the future for the treatment of autoimmune disorders, lymphoma and B cell immunodeficiencies. Therefore, the structure, expression, receptors, biological function and clinical application of BAFF are briefly summarized in this review.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Linfócitos B
/
Alergia e Imunologia
/
Fator Ativador de Células B
/
Receptor do Fator Ativador de Células B
/
Antígeno de Maturação de Linfócitos B
/
Proteína Transmembrana Ativadora e Interagente do CAML
/
Imunidade
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2006
Tipo de documento:
Artigo
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