Expression and role of beta-catenin in acute leukemia bone marrow cells / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 460-463, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-233568
ABSTRACT
The aim of this study was to explore the expression of beta-catenin in acute leukemia bone marrow cells and its role in the development of acute leukemia. The expression of beta-catenin of bone marrow cells was detected by immunocytochemistry and flow cytometry in 20 cases of newly diagnosed acute leukemia. Meanwhile the expression of the proliferating index Ki-67 was detected by immunocytochemistry. The results showed that the expression of beta-catenin and Ki-67 in acute leukemia bone marrow cells was significantly higher than those in control group (P < 0.05). The migration of beta-catenin from cytoplasm to nuclear was observed in acute leukemia bone marrow cells. There was a positive correlation between the expressions of beta-catenin and Ki-67 in all the cases and the Pearson correlation coefficient was 0.845. In conclusion, the expression of beta-catenin was significantly high in acute leukemia bone marrow cells and showed a positive correlation with the cell proliferation. It suggests that beta-catenin may be involved in the development of acute leukemia through promoting the excessive proliferation of cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Células da Medula Óssea
/
Imuno-Histoquímica
/
Leucemia
/
Doença Aguda
/
Antígeno Ki-67
/
Beta Catenina
/
Citometria de Fluxo
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2006
Tipo de documento:
Artigo
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