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HLA- haploidentical donor hematopoietic transplantation for severe aplastic anemia achieved comparable outcomes with HLA- unrelated donor transplantation / 中华血液学杂志
Chinese Journal of Hematology ; (12): 35-38, 2016.
Artigo em Chinês | WPRIM | ID: wpr-234037
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy of HLA- haploidentical donor hematopoietic transplantation (Haplo- HSCT)for severe aplastic anemia (SAA)by compared with the same period of unrelated donor transplantation (UD- HSCT).</p><p><b>METHODS</b>Of a cohort of 50 SAA patients between September 2012 and July 2014, 26 patients underwent UD- HSCT and 24 patients Haplo- HSCT.</p><p><b>RESULTS</b>OS rate was 91.3% with a median follow-up of 9 (2-26)months. According to transplant type, there was no significant difference between UD- and Haplo-HSCT (96.1%vs 86.0%,P=0.30). 3 of 50 (6%)patients had primary engraft failure. Haplo- HSCT developed higher significantly incidence of Ⅱ- Ⅳ aGVHD (37.5%vs 3.83%,P=0.003)and cGVHD (37.5%vs 15.3%,P=0.030)than UD-HSCT. Haplo-HSCT also had significantly higher incidences of CMV viremia (78.2%vs 46.1%,P=0.005)and EBV viremia (43.1%vs 16.0%,P=0.040), respectively than UD-HSCT. But the incidences of hemorrhagic cystitis were similar between two transplant types (39.1%vs 23.0%,P=0.120).</p><p><b>CONCLUSION</b>This study showed favorable outcome of Haplo-HSCT for SAA, which was comparable with UD-HSCT.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Terapêutica / Incidência / Resultado do Tratamento / Transplante de Células-Tronco Hematopoéticas / Doadores não Relacionados / Anemia Aplástica Tipo de estudo: Estudo de incidência / Estudo prognóstico Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Hematology Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Terapêutica / Incidência / Resultado do Tratamento / Transplante de Células-Tronco Hematopoéticas / Doadores não Relacionados / Anemia Aplástica Tipo de estudo: Estudo de incidência / Estudo prognóstico Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Hematology Ano de publicação: 2016 Tipo de documento: Artigo