Gene atm and chronic lymphocytic leukemia - review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1242-1246, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-234258
ABSTRACT
The ataxia telangiectasia mutated gene (atm) is a tumor-suppressing gene, locates in the human chromosome 11q22-23. This gene mainly participates in recognition and repairment of DNA damage and plays a critical role in signal transduction pathway induced by double strand breaks (DSB). In chronic lymphocytic leukemia (CLL) there is high frequency of loss of heterozygosity (LOH) and mutation of atm gene, which related to pathopoiesis and progression of CLL. This article reviewed the progress of recent studies on the characteristics and mechanism of atm gene, as well as its role in the pathogenesis of CLL.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Leucemia Linfocítica Crônica de Células B
/
Proteínas Serina-Treonina Quinases
/
Deleção de Genes
/
Proteínas de Ciclo Celular
/
Proteínas Supressoras de Tumor
/
Proteínas de Ligação a DNA
/
Proteínas Mutadas de Ataxia Telangiectasia
/
Genética
/
Mutação
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2008
Tipo de documento:
Artigo
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