No association of vascular endothelial growth factor A gene rs9369425 polymorphism with glucose metabolism in Chinese Han population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 457-459, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-234383
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between the vascular endothelial growth factor A gene (VEGFA) rs9369425 single nucleotide polymorphism (SNP) and type 2 diabetes in Chinese Han population.</p><p><b>METHODS</b>One thousand eight hundred and ninety two type 2 diabetes patients and 1808 controls with normal glucose were recruited in this study. Phenotypes including body mass index, waist, waist hip ratio, plasma glucose and serum insulin levels of blood obtained both at 0 and 120 minute during standard 75-gram glucose oral glucose tolerance tests, were analyzed. Insulin resistance and beta cell function were assessed by homeostasis model assessment (HOMA-IR and HOMA-B). Genotyping was performed by time-of-light mass spectrum using a Sequenom platform.</p><p><b>RESULTS</b>The frequencies of minor allele G in the diabetic patients and controls were 10.8% and 11.3% respectively. No significant difference of allele distribution was detected between the cases and controls (P=0.5086). No significant difference (P>0.05) was detected on the association between rs9369425 SNP and clinical phenotypes.</p><p><b>CONCLUSION</b>VEGFA rs9369425 was not associated with type 2 diabetes in Chinese Han population. Whether there is association in any other loci in this gene remained to be investigated.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Glicemia
/
Resistência à Insulina
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Fator A de Crescimento do Endotélio Vascular
/
Grupos Populacionais
/
Povo Asiático
/
Diabetes Mellitus Tipo 2
/
Alelos
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2010
Tipo de documento:
Artigo
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