To identify a novel HLA-DRB1 allele in Chinese by sequencing / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 333-334, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-234407
ABSTRACT
<p><b>OBJECTIVE</b>To identify a novel HLA-DRB1 allele in Chinese.</p><p><b>METHODS</b>A novel HLA-DR allele was detected by PCR-SSP and SBT in a patient with leukemia.</p><p><b>RESULTS</b>The sequence of the novel allele was different from all other known alleles. The novel allele differed from the closet matching allele HLA-DRB1*1404 by one nucleotide substitution in exon 2, at position 33 T>C, this resulted in an amino acid change from Tyr to His at codon 17.</p><p><b>CONCLUSION</b>The novel allele is confirmed as a new HLA allele and it was officially named HLA-DRB1*1461 by WHO Nomenclature Committee in May, 2006.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antígenos HLA-DR
/
Reação em Cadeia da Polimerase
/
Análise de Sequência de DNA
/
Povo Asiático
/
Alelos
/
Cadeias HLA-DRB1
/
Genética
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS