Effects of propofol, etomidate and ethanol on GPCR mRNA expression in Daphnia pulex / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 827-832, 2014.
Article
em Zh
| WPRIM
| ID: wpr-234502
Biblioteca responsável:
WPRO
ABSTRACT
The mechanisms of general anesthesia, which was introduced about 170 years ago, remain poorly under- stood. Even less well understood are the effects of general anesthesia on the human body. Recently we identified 18 G-protein coupled receptor (GPCR) genes of Daphnia pulex, an invertebrate model organism. Phylogenetic analysis identified these genes to be the homologs of the human γ-aminobutyric acid, type B (GABAB) receptor, metabotropic glutamate receptors (mGluR), adrenergic receptor, serotonin (5-HT) receptor, dopamine receptor and muscarinic acetylcholine receptor (mAChR). Using reverse transcription and quantitative PCR techniques, we systematically measured the effects of propofol, etomidate and ethanol on these 18 GPCR mRNA expressions in Daphnia pulex.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
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Filogenia
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RNA Mensageiro
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Propofol
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Receptores de GABA-B
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Daphnia
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Etanol
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Etomidato
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Genética
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Metabolismo
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2014
Tipo de documento:
Article