Characteristics of JC virus VLP-Z for targeting gene delivery / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 572-576, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-234609
ABSTRACT
The characteristics of virus-like particle (VLP) of JC virus (JCV) as a vector for targeting gene delivery was determined. The exogenous DNA (PUC19) packaged in VLP-Z was resistant to DNase I. VLP-Z was able to deliver a reporter plasmid pEGFP-N1 into HeLa cells and the green fluorescent reporter protein was expressed in these cells. VLP-Z was also able to bind IgG by interaction with the Z fragment of VLP-Z and IgG. These results suggested that VLP-Z might be used as a vector to deliver therapeutic genes to target cells with incorporating IgG antibodies.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Vírion
/
Imunoglobulina G
/
Células HeLa
/
Terapia Genética
/
Técnicas de Transferência de Genes
/
Vírus JC
/
Marcação de Genes
/
Vetores Genéticos
/
Genética
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2013
Tipo de documento:
Artigo
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