Comparative study of Modified Xiaoyao Pill combining amitriptyline on therapeutic effect and compliance in treating patients with depression / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 642-644, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-234719
ABSTRACT
<p><b>OBJECTIVE</b>To comparatively observe the curative effect, adverse reaction and compliance of Modified Xiaoyao Pill combining amitriptyline (MXP-At) in treating patients with depression.</p><p><b>METHODS</b>Sixty-four patients with diagnosis of depression matched to the Chinese Classification of Mental Disorders (CCMD-3) were randomly assigned to 2 groups, the treatment group treated with MXP-At and the control group with fluoxeline, 32 cases in each group. The curative effect was evaluated by Hamilton depression (HAMD) scale and the adverse reaction was recorded before treatment and at the 2nd, 4th and 12th week of the treatment. Patients were regularly followed up from the 12th week to the 24 th week. The curative effect and compliance in the two groups were compared.</p><p><b>RESULTS</b>The HAMD score dropped in both groups from the 2nd week of the treatment, and at that time, it was lower in the control group than that in the treatment group (P < 0.05); but at the 4th week, no significant difference was found in the therapeutic effect and the HAMD score between the two groups. However, 3 and 14 cases in the treatment and the control group were relapsed during the 12 weeks of follow-up respectively.</p><p><b>CONCLUSION</b>MXP-At shows a curative effect similar to fluoxetine on depression but with less adverse reaction, and is not expensive.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Medicamentos de Ervas Chinesas
/
Seguimentos
/
Cooperação do Paciente
/
Resultado do Tratamento
/
Usos Terapêuticos
/
Depressão
/
Tratamento Farmacológico
/
Quimioterapia Combinada
/
Amitriptilina
/
Fitoterapia
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2007
Tipo de documento:
Artigo
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