Effects of tetramethylpyrazine on brain oxidative damage induced by intracerebral perfusion of L-DOPA in rats with Parkinson's disease / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 629-632, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-234723
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of tetramethylpyrazine (TMP) on brain oxidative damage induced by intracerebral perfusion of levodopa (L-DOPA) in rats with Parkinson's disease (PD).</p><p><b>METHODS</b>PD model rats were induced by intracerebral injection of 6-hydroxyl dopamine (6-OHDA) and perfused in brain with L-DOPA using microdialysis technique. Changes in levels of 2,3-dihydroxy benzyl acid (2.3-DHBA) and 2,5-dihydroxy benzyl acid (2,5-DHBA) in striatum of rats, formed by extracellular hydroxyl radical from salicylic acid capturing, were dynamically observed at various time points by HPLC-ED.</p><p><b>RESULTS</b>After treatment with L-DOPA, 2,3-DHBA and 2,5-DHBA in the model group showed significantly higher levels at 6 and 7 time points as compared with those in the sham-operated group at the corresponding time points (P <0.05 or P< 0.01), while these abnormal elevations were significantly inhibited in the TMP treated groups, either in large or small dose (P<0.05 or P<0.01).</p><p><b>CONCLUSION</b>TMP could reduce the L-DOPA induced brain oxidative damage in PD rats.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson Secundária
/
Patologia
/
Pirazinas
/
Levodopa
/
Distribuição Aleatória
/
Catecóis
/
Anti-Inflamatórios não Esteroides
/
Cromatografia Líquida de Alta Pressão
/
Oxidopamina
/
Ratos Sprague-Dawley
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2007
Tipo de documento:
Artigo
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