Preventive effect of shenfu injection on hepatic ischemia-reperfusion injury in rats / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 61-63, 2006.
Article
em Zh
| WPRIM
| ID: wpr-234807
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective effects of Shenfu Injection (SI) on hepatic ischemia-reperfusion injury in rats.</p><p><b>METHODS</b>Partial liver ischemia-reperfusion model under room temperature was established in 60 rats, which were divided into the control group and the treated group randomly and each group was again classified into 3 subgroups with 30 min, 60 min and 90 min hepatic ischemia time rspectively. Rats in the treated group were injected with SI 10 ml/kg every day, while the control group treated with normal saline. Survival rate after 1 week was observed, the serum levels of aspartate aminotransferase (AST), malondialde hyde (MDA), surperoxide dismutase (SOD), tumor nicrosis factor alpha (TNF-a) and endothelin (ET) were detected, and hepatic biopsy was performed with light and electronic microscope.</p><p><b>RESULTS</b>The survival rate in the treated subgroup with 90 min' ischemia after 1 week was 90%, higher than that in the control subgroup significantly (P <0. 05), which was 60% ; and serum levels of AST, MDA, TNF-alpha and ET were lower and SOD was higher significantly (all P <0.05), as well as the degenerative and necrotic degree of hepatocyte and sinusoidal endothelial cells was lighter in the 3 treated subgroups, compared with the control group.</p><p><b>CONCLUSION</b>Shenfu injection can eliminate oxygen free radical during hepatic ishemia-reperfusion so as to has a protective effect and attenuate hepatic ischemia reperfusion injury.</p>
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Índice:
WPRIM
Assunto principal:
Aspartato Aminotransferases
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Superóxido Dismutase
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Sangue
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Medicamentos de Ervas Chinesas
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Traumatismo por Reperfusão
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Endotelinas
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Fator de Necrose Tumoral alfa
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Resultado do Tratamento
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Substâncias Protetoras
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Usos Terapêuticos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2006
Tipo de documento:
Article