Protective mechanisms of radix salviae miltiorrhizae against chronic alcoholic liver injury in mice / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 425-428, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-234857
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective mechanisms of Radix Salviae miltiorrhizae (RSM) on chronic alcoholic liver injury in mice.</p><p><b>METHODS</b>The chronic alcoholic liver injury mouse model was established. The morphologic change of hepatic tissue was observed with hematoxylin-eosin (HE) staining; the levels of toll-like receptor-4 (TLR-4) mRNA in hepatic tissue and hemeoxygenase-1 (HO-1) mRNA were determined using reverse transcription polymerase chain reaction (RT-PCR) technique; and the expression of TLR-4 protein was determined by immunohistochemistry method.</p><p><b>RESULTS</b>RSM could alleviate the fatty degeneration and adiponecrosis of hepatic cells induced by alcohol, down-regulate the expressions of TLR-4 mRNA and HO-1 mRNA, and significantly decrease the number of TLR-4 positive cells.</p><p><b>CONCLUSION</b>RSM could prevent liver injury from alcohol by way of influencing TLR-4 signal transcription.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
RNA Mensageiro
/
Medicamentos de Ervas Chinesas
/
Glicoproteínas de Membrana
/
Receptores de Superfície Celular
/
Salvia miltiorrhiza
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Heme Oxigenase-1
/
Receptores Toll-Like
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2005
Tipo de documento:
Artigo
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