Expressions of OCT4 and CD133 and their correlation in colonic cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1434-1436, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-235107
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of Oct4 and CD133 and their correlation in colonic cancer.</p><p><b>METHODS</b>The expression of Oct4 and CD133 were detected by immunohistochemistry in 30 colon cancer specimens and the paired adjacent tissues.</p><p><b>RESULTS</b>The positivity rates of Oct4 and CD133 expression were 83.3% (25/30) and 73.3% (22/30) in colonic cancer tissue, respectively, and their expressions were positively correlated (r=0.586, P<0.05). The matched adjacent tissues showed significantly lower levels of Oct4 and CD133 expressions (P<0.01).</p><p><b>CONCLUSION</b>The expressions of Oct4 and CD133 are upregulated in colonic cancer compared with those in the adjacent tissues and show a positive correlation. Oct4 and CD133 may play an important role in the development of colon cancer.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Peptídeos
/
Cirurgia Geral
/
Glicoproteínas
/
Imunoquímica
/
Adenocarcinoma
/
Antígenos CD
/
Regulação para Cima
/
Neoplasias do Colo
/
Fator 3 de Transcrição de Octâmero
/
Antígeno AC133
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2011
Tipo de documento:
Artigo
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