Study on anti-atherosclerotic mechanisms of divided functional recipes of dahuang zhechong pill in rabbits / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1077-1081, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-235258
ABSTRACT
<p><b>OBJECTIVE</b>To study anti-atherosclerotic mechanisms of divided functional recipes of Dahuang Zhechong pill (DHZCP) in rabbits.</p><p><b>METHOD</b>The atherosclerotic rabbit model was established by high fat feeding combined with immune endothelial injury. Male New Zealand rabbits were divided into 9 groups normal control group, model control group, Danshen positive control group, and 6 DHZCP-divided groups including divided functional recipes No. 1, 2, 3 with low and high doses for each divided recipe. After intragastric administration for 60 days, blood lipids and serum MDA and NO levels and SOD activity and plasma ET concentration, and contents of hydroxyproline and proteins in the vascular wall were determined.</p><p><b>RESULT</b>Compared with the model group, the level of blood lipids did not significantly change, serum MDA and ET levels, and the contents of hydroxyproline and proteins in the vascular wall significantly decreased (P < 0.05), and SOD activity and NO level increased in the divided functional recipes (all P < 0.05).</p><p><b>CONCLUSION</b>The divided functional recipes of DHZCP can inhibit development of atherosclerosis via a non-lowering lipid mechanisms, including anti-peroxidation of lipids, protection of endothelial function, and decrease of formation of extracellular matrix by reducing synthesis of collage and protein on the vascular wall. Among them, the divided functional recipe No. 1 exhibits the most obvious effect.</p>
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Aorta
/
Patologia
/
Farmacologia
/
Plantas Medicinais
/
Rheum
/
Superóxido Dismutase
/
Sangue
/
Medicamentos de Ervas Chinesas
/
Materia Medica
/
Distribuição Aleatória
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2007
Tipo de documento:
Artigo
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