Inhibitory effect of taspine on mouse S180 sarcoma and its mechanism / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 953-956, 2007.
Article
em Zh
| WPRIM
| ID: wpr-235282
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the inhibition effect of taspine on mouse S180 sarcoma and its mechanism.</p><p><b>METHOD</b>The mouse S180 sarcoma model was established and used to observe the antitumor activity of taspine. The microvessel density and protein expressing of the VEGF, bFGF, Bcl-2 and Bax in the tumor were measured by immunohistochemistry.</p><p><b>RESULT</b>Taspine showed antitumor activity on the mouse S180 sarcoma in a good dose-dependent manner. The inhibition rates on tumor of taspine at low, middle and high concentrations were 39.08% , 43.99% and 48.60%, respectively. The microvessel density and protein expressing of the VEGF, bFGF, Bcl-2 and Bax in the tumor were decreased compared with the negative control. The ratio of Bax to Bcl-2 was increased.</p><p><b>CONCLUSION</b>Taspine has antitumor effect on the S180 sarcoma, and the mechanism may be through the way of decreasing the expressing of the VEGF, bFGF, Bcl-2 and Bax and inducing the vascular endothelial cell apoptosis.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
/
Plantas Medicinais
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Sarcoma 180
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Química
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Fator 2 de Crescimento de Fibroblastos
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Raízes de Plantas
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Proteínas Proto-Oncogênicas c-bcl-2
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Berberidaceae
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Linhagem Celular Tumoral
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Fator A de Crescimento do Endotélio Vascular
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2007
Tipo de documento:
Article