Effects of retinol acid and triiodothyronine on alleviating the impairment of cognitive function by sleep deprivation / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 294-300, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-235376
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effects of retinol acid (RA) and triiodothyronine (T3) on alleviating the impairment of cognitive function by sleep deprivation (SD).</p><p><b>METHODS</b>Male Wistar rats were divided into 4 groups control group (C group), sleep deprivation group (SD group), sleep deprivation + RA group (SD + RA group) and sleep deprivation + T3 group (SD + T3 group). Open field test (OFT) was used to observe the nervous behavior of the rats after SD and electrophysiological brain stereotactic method was used to test long-term potentiation (LTP) in dentate gyrus (DG) of the rats. Ng protein expression was determined by Western blot.</p><p><b>RESULTS</b>Compared with the SD group, the number of crossing in OFT, the changes of amplitude of population spike (PS) and the expression of Ng protein in hippocampus were higher significantly in the SD + RA and SD + T3 groups. All of these had not significant difference comparing with the C group.</p><p><b>CONCLUSION</b>RA and T3 may alleviate the restrain state of neural system after SD by augmenting the expression of Ng protein in hippocampus.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Psicologia
/
Privação do Sono
/
Tri-Iodotironina
/
Vitamina A
/
Ratos Wistar
/
Cognição
/
Potenciação de Longa Duração
/
Giro Denteado
/
Neurogranina
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2013
Tipo de documento:
Artigo
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