Testing immunogenicity of recombinant antibody by surface plasmon resonance / 药学学报
Acta Pharmaceutica Sinica
;
(12): 532-535, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-235632
ABSTRACT
With the development of bio-technological drugs, drug immunogenicity evaluation has become key factor of clarifying safety and efficacy of these drugs. It has become the focus to establish a stable and reliable evaluation system. Due to the advantages such as continuous real-time monitoring, surface plasmon resonance (SPR) technology has been widely used in bio-technological drugs immunogenicity assessments. Our study applied this technology to detect anti-drug antibody (ADA) of a recombinant human anti-rabies monoclonal antibody NM57 in the sera of 48 volunteers admitted in phase I clinical trials. This method could satisfy the basic requirements of detection of ADA.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Vírus da Raiva
/
Sangue
/
Proteínas Recombinantes
/
Anticorpos Anti-Idiotípicos
/
Ressonância de Plasmônio de Superfície
/
Alergia e Imunologia
/
Anticorpos Monoclonais
/
Anticorpos Antivirais
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2013
Tipo de documento:
Artigo
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