Design, synthesis, and PPARgamma agonistic activity of novel indenone derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 508-513, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-235636
ABSTRACT
Agonists of peroxisome proliferator-activated receptor gamma (PPARgamma) are of interest as a treatment of type II diabetes, and indenone derivatives are a new class of non-TZD PPARgamma agonists. Based on existing indenone derivatives, a series of novel ones have been designed and synthesized. Meanwhile the structures have been comfirmed with 1H NMR and MS. Among them, 17b and 19 showed higher agonistic activities than rosiglitazone.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Espectrometria de Massas
/
Relação Estrutura-Atividade
/
Espectroscopia de Ressonância Magnética
/
Desenho de Fármacos
/
Estrutura Molecular
/
Química
/
Tiazolidinedionas
/
PPAR gama
/
Hipoglicemiantes
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2013
Tipo de documento:
Artigo
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