Effects of long-term sleep deprivation on mitochondria stress in locus coeruleus and the tyrosine hydroxylasic projection in mice / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 153-156, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-236361
ABSTRACT
<p><b>OBJECTIVE</b>To observe the changes of mitochondria stress in locus coeruleus and the tyrosine hydroxylasic projection after long-term sleep deprivation.</p><p><b>METHODS</b>Sleep deprivation mice model was set up by employing "novel environments" method. The expression of NAD -dependent deacetylase Sirtuin type 3 (SIRT3), which regulates mitochondrial energy production and oxidative stress, and heat shock protein 60 (HSP60), a major biomarker of mitochondrial stress, and the tyrosine hydroxylasic projection from locus coeruleus were analyzed after a 5-day sleep deprivation.</p><p><b>RESULTS</b>Compared to the control group, the expression of SIRT3 in locus coeruleus was significantly decreased in respouse to long-term sleep deprivation, while the expression of HSP60 was significantly increased. In addition, relative to control group, pereentage area of the tyrosine hydroxylasic projection to anterior cingulate cortex was substantial decreased in long-term sleep deprivation group.</p><p><b>CONCLUSION</b>Long-term sleep deprivation induced the decreased level of SIRT3 expression and the elevation of mitochondrial stress in locus coenileus, which may further lead to the loss of tyrosine hydroxylasic projection in mice.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Privação do Sono
/
Tirosina
/
Locus Cerúleo
/
Estresse Oxidativo
/
Chaperonina 60
/
Proteínas Mitocondriais
/
Sirtuína 3
/
Metabolismo
/
Mitocôndrias
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2014
Tipo de documento:
Artigo
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