Association and interaction between the components of metabolic syndrome and cardiovascular disease / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 644-647, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-236435
ABSTRACT
<p><b>OBJECTIVE</b>To explore the association and interaction between the components of metabolic syndrome (MS) and cardiovascular disease (CVD).</p><p><b>METHOD</b>In this cohort study, participants (total 3598, male 1451) were recruited and followed up for five years from the program "prevention of multiple metabolic disorders and MS in Jiangsu province". We used modified Asian criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) to define the presence of MS. COX regression was used to analyze the association between the MS and its components with CVD; both the multiplication of blood pressure (BP) and 2, 3, or 4 other components of MS in the logistic regression model and the estimation of the relative excess risk due to interaction (RERI), the attributable proportion due to interaction (AP), and the synergy index (S) and 95% confidence intervals (95%CI) were used to evaluate the interactions between the components of MS.</p><p><b>RESULTS</b>After adjustment for traditional CVD risks, the adjusted risk ratio (aRR) of CVD was 2.49 (95%CI 1.59 - 3.90) in the MS group compared with the non-MS group at baseline. The aRRs of MS components to CVD were as follows 1.44 (95%CI 0.88 - 2.37) for waist circumference; 2.84 (95%CI 1.73 - 4.68) for BP; 1.31 (95%CI 0.83 - 2.07) for low high density lipoprotein; 1.84 (95%CI 1.19 - 2.85) for triglyceride; 1.55(95%CI 0.98 - 2.45) for fasting plasma glucose, respectively. BP was the single component significantly related to CVD (aRR = 2.58, 95%CI 1.55 - 4.29). The risk of CVD was significantly increased (aOR = 4.47, 95%CI 2.35 - 8.51) when BP was combined with 2, 3 or 4 other components of MS in the participants.</p><p><b>CONCLUSIONS</b>Only BP is an independent CVD risk factor in the components of MS, the risk of CVD was significantly increased when BP was combined with other components of MS in this cohort.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pressão Sanguínea
/
Doenças Cardiovasculares
/
China
/
Epidemiologia
/
Fatores de Risco
/
Estudos de Coortes
/
Síndrome Metabólica
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2009
Tipo de documento:
Artigo
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